The Spectrum of Sepsis

Bacteremia bacteria in the blood
SIRS 2 or more of the following: tempreature > 38 or < 36, HR > 90, RR > 20, PaCO2 < 32, WBC>12K, <4K, or >10% bands
Sepsis SIRS with definitive e/o infection
Severe Sepsis Sepsis with organ dysfunction, hypoperfusion, hypotension (SBP<90) or >40 decrease from baseline
Septic Shock Sepsis with hypotension despite adequate fluid resuscitation (500mL bolus) and perfusion abnormalities that may include oliguria, altered mental status, lactic acidosis
Multiple Organ Dysfunction
presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention